PXD075662

PXD075662 is an original dataset announced via ProteomeXchange.

Title	IP-MS Results of Nipped-B-like Protein in Mouse Ovaries
Description	This project utilizes Immunoprecipitation coupled with Mass Spectrometry (IP-MS) to comprehensively map the interactome of the NIPBL protein within mouse ovarian tissue. As a critical cohesin loader regulating chromatin architecture and gene expression, NIPBL's specific binding partners in the ovary remain largely uncharacterized. By isolating NIPBL complexes from murine ovaries and identifying associated proteins via high-resolution MS, this study aims to uncover novel protein-protein interactions essential for oocyte development, meiotic cohesion, and folliculogenesis. The resulting dataset provides crucial insights into the molecular mechanisms governing female fertility and may reveal pathogenic pathways linked to cohesin-related reproductive disorders.
HostingRepository	iProX
AnnounceDate	2026-03-16
AnnouncementXML	Submission_2026-04-19_19:32:59.203.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaofan Sun
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-16 01:00:31	ID requested
⏵ 1	2026-04-19 19:32:59	announced

Dataset with its publication pending

submitter keyword: Nipped-B-like protein, Immunoprecipitation-Mass Spectrometr, Mouse ovary

Bo Xiong
contact affiliation	College of Animal Sciences, Zhejiang University
contact email	xiongbo@zju.edu.cn
lab head
Xiaofan Sun
contact affiliation	College of Animal Science and Technology, Nanjing Agricultural University
contact email	2022205021@stu.njau.edu.cn
dataset submitter

iProX dataset URI