⮝ Full datasets listing
PXD075646
PXD075646 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic validation of cell death mechanisms of HDQ-mediated copper transporting |
| Description | Inspired by a bacterial SUF-system inhibitor, we integrated its core scaffold with copper-transporting 8-hydroxyquinoline moiety, yielding four derivatives (HDQ, HDQ-S, HDQ-Ph, and HDQ-Me). Functionally, HDQ-mediated copper loading triggers hallmark cuproptosis features, induces DNA damage, disrupts Fe-S proteins,and collapses ATP production, creating synergistic lethality. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-13 |
| AnnouncementXML | Submission_2026-03-15_20:29:41.974.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xiang Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-15 20:29:06 | ID requested | |
| ⏵ 1 | 2026-03-15 20:29:42 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: HDQ, Fe-S proteins, Cuproptosis |
Contact List
| Xiang Li | |
|---|---|
| contact affiliation | Hubei University |
| contact email | lixiang199284@hubu.edu.cn |
| lab head | |
| Xiang Li | |
| contact affiliation | Hubei University |
| contact email | lixiang199284@hubu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
