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PXD075587
PXD075587 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mass spectrometry-based proteomics screening identifies an IgA–C3 complex associated with disease progression in IgA nephropathy |
| Description | IgA1 immune complexes (IgA1-ICs) containing galactose-deficient IgA1 (GdIgA1) play a critical role in the formation of renal immune deposits in IgA nephropathy (IgAN). Previously, we found that patients with IgA myeloma (IgAMM) without renal IgA deposition exhibit unexpectedly elevated plasma levels of GdIgA1 and poly-IgA complexes. Despite these insights, the pathogenic O-glycosylation profile of IgA and the molecular composition of circulating IgA1-ICs in IgAN remain incompletely characterized. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-13 |
| AnnouncementXML | Submission_2026-03-12_19:22:11.335.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yong Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | deaminated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-12 19:21:43 | ID requested | |
| ⏵ 1 | 2026-03-12 19:22:11 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: IgA1, IgAN |
Contact List
| Yong Zhang | |
|---|---|
| contact affiliation | West China Hospital, Sichuan University |
| contact email | nankai1989@foxmail.com |
| lab head | |
| Yong Zhang | |
| contact affiliation | West China Hospital, Sichuan University |
| contact email | nankai1989@foxmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
