PXD075574 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting RuvBL1 disrupts mitochondrial metabolism and structure in hepatocellular carcinoma |
| Description | Huh7 cells endogenously tagged with OMP25HA and OMP25MYC were treated with the RuvBL1/2 small molecule inhibitor CB-6644 (1uM for 48h. Mitochondria were immunoprecipitated with anti-HA magnetic beads. OMP25MYC-tagged mitochondria served as negative control for IP. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-24 |
| AnnouncementXML | Submission_2026-08-23_16:10:36.939.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD075574 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Tommaso Mello |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-12 12:53:12 | ID requested | |
| ⏵ 1 | 2026-08-23 16:10:37 | announced | |
Publication List
| 10.1016/j.jhepr.2026.101858; |
| 10.6019/PXD075574; |
| Mello T, Simeone I, Guida A, Papini D, Begnozzi F, Santi A, Guasti D, Nardini P, Polvani S, Lulli M, Bereshchenko O, Ceni E, Curto A, Pinton P, Bonora M, Galli A, Targeting RuvBL1 disrupts mitochondrial metabolism and structure in hepatocellular carcinoma. JHEP Rep, 8(7):101858(2026) [pubmed] |
Keyword List
| submitter keyword: ATPsynthase, HCC, RuvBL1, mitochondria, Huh7,CB-6644 |
Contact List
| Tommaso Mello |
|---|
| contact affiliation | University of Florence (Italy) |
| contact email | tommaso.mello@unifi.it |
| lab head | |
| Tommaso Mello |
|---|
| contact affiliation | University of Florence |
| contact email | tommaso.mello@unifi.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD075574 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD075574
- Label: PRIDE project
- Name: Targeting RuvBL1 disrupts mitochondrial metabolism and structure in hepatocellular carcinoma
