PXD075484 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Surface and global proteome profiling of osteosarcoma patient derived xenografts |
| Description | This study analyzed 22 unique OS patient-derived xenografts (PDXs) using proteomics to identify surface proteins for potential immunotherapeutic targeting. Plasma membranes were enriched using density gradient ultracentrifugation and compared to a reference standard of 12 immortalized non-OS cell lines prepared in a similar manner. In parallel, global proteome analysis was carried out on all samples to place the identified surface proteins within the context of deregulated OS pathways. All models were analyzed by Tandem Mass Tags (TMT)-based mass spectrometry to quantify identified proteins. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-28 |
| AnnouncementXML | Submission_2026-07-27_22:26:34.597.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Gian Luca Negri |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-10 21:53:23 | ID requested | |
| ⏵ 1 | 2026-07-27 22:26:35 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: osteosarcoma |
Contact List
| Gregg Morin |
|---|
| contact affiliation | Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver V5Z 1L3, Canada. |
| contact email | gmorin@bcgsc.ca |
| lab head | |
| Gian Luca Negri |
|---|
| contact affiliation | Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver V5Z 1L3, Canada. |
| contact email | gnegri@bcgsc.ca |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD075484 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD075484
- Label: PRIDE project
- Name: Surface and global proteome profiling of osteosarcoma patient derived xenografts
