PXD075440

PXD075440 is an original dataset announced via ProteomeXchange.

Title	Arachidonoyl-taurine protects from diet-induced hepatic steatosis and inflammation - Time course experiment
Description	Metabolic dysfunction-associated steatotic liver disease and its progressive and inflamma-tory form metabolic dysfunction-associated steatohepatitis represents a global health challenge, with limited treatment options available. In this study we identified an endoge-nous, understudied omega-6 fatty acid metabolite, arachidonoyl-taurine (ARA-T), capable of mitigating liver disease. ARA-T levels increased in human plasma of chronic and acute fatty liver and their abundance can be driven in humans and mice by dietary supplementa-tion of arachidonic acid. Surprisingly, our genetic model of elevated circulating ARA-T levels prevented inflammation and hepatic steatosis by increased uptake and turnover of fatty ac-ids in the liver. Pharmacological administration of ARA-T reduced liver weight and diet-induced hepatic lipid deposition in mice, demonstrating its potential to protect against and reverse the progression of liver disease. Thus, ARA-T may represent a way to protect against pro-inflammatory actions of omega-6 fatty acids thereby contributing to regulation of in-flammation and accumulation of hepatic lipids.
HostingRepository	PRIDE
AnnounceDate	2026-05-20
AnnouncementXML	Submission_2026-05-20_06:29:07.079.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ivan Bradić
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-10 04:35:51	ID requested
⏵ 1	2026-05-20 06:29:07	announced

10.1016/J.JHEP.2026.04.033;

submitter keyword: MASLD, ARA-T, endogenous lipid metabolite, fatty acid oxidation, arachidonic acid,N-acyl taurine

Trisha Jean Grevengoed
contact affiliation	Department of Biomedical Sciences, University of Copenhagen
contact email	grevengoed@sund.ku.dk
lab head
Ivan Bradić
contact affiliation	University of Southern Denmark
contact email	ibradic95@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD075440

PRIDE project URI

• PRIDE
  1. PXD075440
     1. Label: PRIDE project
     2. Name: Arachidonoyl-taurine protects from diet-induced hepatic steatosis and inflammation - Time course experiment