⮝ Full datasets listing
PXD075364
PXD075364 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Plasma Extracellular-Vesicle Proteomics Nominates Candidate Biomarkers of 177Lu-PSMA-617 Outcomes in Metastatic Prostate Cancer Patients |
| Description | 177Lu-PSMA-617 represents a transformative treatment for metastatic castration-resistant prostate cancer (mCRPC), yet biomarkers of benefit beyond PSMA-PET imaging remain lacking. Here, we present findings from a prospective study of 100 mCRPC patients receiving 177Lu-PSMA-617, using shotgun proteomics to profile plasma-derived extracellular vesicle (EV) proteins alongside PSMA-positive circulating tumor cell (CTC)enumeration. We identify 5,137 EV-derived proteins, including the cell-surface targets PSMA, B7-H3, Trop-2, and STEAP1, with high levels of these proteins associating with worse overall survival (OS). All four EV-proteins positively correlate with molecular tumor volume on PSMA-PET imaging, serum PSA, and serum alkaline phosphatase. CTC subpopulations, including PSMA+/EpCAM+ and PSMA-/EpCAM+ cells, associate with worse progression-free survival (PFS) and OS. Pathway analysis reveals that p53 upregulation associates with poor PFS and OS, while an activated E2F pathway unexpectedly portends better PFS and OS. These findings support the integration of liquid-biopsy proteomics into biomarker-driven mCRPC trials to improve patient stratification |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-03-09 |
| AnnouncementXML | Submission_2026-03-09_05:10:19.960.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ali Arafa |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-08 08:35:24 | ID requested | |
| ⏵ 1 | 2026-03-09 05:10:20 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Prostate cancer, Extracellular Vesicles, Castration resistant prostate cancer, plasma, Radioligand therapy, liquid biopsies, PSMA, B7H3, Trop2, STEAP1, DatasetType:Proteomics |
Contact List
| Emmanuel Antonarakis | |
|---|---|
| contact affiliation | University of Minnesota |
| contact email | anton401@umn.edu |
| lab head | |
| Ali Arafa | |
| contact affiliation | University of Minnesota |
| contact email | aarafa@umn.edu |
| lab head | |
| Justin M. Drake PhD | |
| contact affiliation | University Minnesota |
| contact email | jdrake@umn.edu |
| lab head | |
| Ali Arafa | |
| contact affiliation | University of Minnesota |
| contact email | aarafa@umn.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v12/MSV000101069/ |
