⮝ Full datasets listing
PXD075361
PXD075361 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer’s disease |
| Description | **Project Description** This dataset contains LC-MS/MS proteomics data generated from human brain samples including control individuals, sporadic Alzheimer’s disease (spAD), and rapidly progressive Alzheimer’s disease (rpAD). Brain tissue samples were subjected to protein extraction followed by short SDS-PAGE separation and in-gel digestion using trypsin. The resulting peptides were analyzed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Mass spectrometric analysis was performed using an Orbitrap Exploris 480 mass spectrometer operated in data-independent acquisition (DIA) mode with a 60-minute LC gradient and approximately 250 ng peptide loading. Each biological sample was analyzed in three technical LC-MS replicates. The dataset also includes IgG negative control samples. Raw data were processed using Spectronaut software with the Pulsar search engine against the UniProtKB Homo sapiens reference proteome database. Carbamidomethylation of cysteine residues was set as a fixed modification, while oxid |
| HostingRepository | jPOST |
| AnnounceDate | 2026-03-08 |
| AnnouncementXML | Submission_2026-03-08_05:33:34.856.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tayyaba saleem |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-08 05:33:31 | ID requested | |
| ⏵ 1 | 2026-03-08 05:33:35 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: TauO, Proteins, Aggregation |
Contact List
| Inga Zerr | |
|---|---|
| lab head | |
| Tayyaba saleem | |
| contact affiliation | UMG |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004458/ |
