PXD075354

PXD075354 is an original dataset announced via ProteomeXchange.

Title	Proteomic identification of primate-specific lncRNA LINC01021 interactors via RNA pull-down MS
Description	Long non-coding RNAs (lncRNAs) play critical regulatory roles in primate-specific biological processes, yet many primate-specific lncRNAs and their protein interactors remain poorly characterized. In this study, we focused on primate-specific lncRNAs as potential drivers of protein interactions. Using RNA affinity pull-down coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS), we identified proteins interacting with LINC01021 in primate-derived cells. Key findings include specific enrichment of RBMS proteins, suggesting a functional role in RNA metabolism or gene regulation. This dataset provides proteomic evidence for primate-specific lncRNA-protein interactions and contributes to understanding evolutionary adaptations in primates.
HostingRepository	PRIDE
AnnounceDate	2026-06-29
AnnouncementXML	Submission_2026-06-28_16:26:29.239.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yan Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-07 11:21:19	ID requested
⏵ 1	2026-06-28 16:26:30	announced

10.1111/acel.70603;

Zhang Y, Hu L, Dong X, Zeng Q, Zi M, Nisar A, Khan S, Bai R, Liu C, Ge M, Pu S, Li G, He Y, A Primate-Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1-Dependent Destabilization of RBMX. Aging Cell, 25(7):e70603(2026) [pubmed]

submitter keyword: long non-coding RNA, proteomics,lncRNA, mass spectrometry, protein-RNA interaction, LINC01021, primate-specific lncRNA, RNA-binding protein, interactome, RBMS, RNA pull-down

Yonghan He
contact affiliation	1. State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China 2. University of Chinese Academy of Sciences, Beijing 100101, China 3. KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650201, China
contact email	heyonghan@mail.kiz.ac.cn
lab head
Yan Zhang
contact affiliation	State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China
contact email	zhangyan1@mail.kiz.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD075354

PRIDE project URI

• PRIDE
  1. PXD075354
     1. Label: PRIDE project
     2. Name: Proteomic identification of primate-specific lncRNA LINC01021 interactors via RNA pull-down MS