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PXD075327
PXD075327 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | LysR type transcriptional regulator TtdR regulates both ethylene glycol and polyhydroxyalkanoate (PHA) metabolism in Pseudomonas umsongensis GO16 Dataset 2 |
| Description | Proteomic analysis was employed to elucidate the regulatory role of TtdR, a LysR-type transcriptional regulator located upstream of the glyoxylate carboligase gene (gcl) in Pseudomonas umsongensis GO16. While the wildtype strain can utilize ethylene glycol (EG) as a sole carbon and energy source, the ΔttdR mutant is unable to grow on EG, confirming TtdR as an activator of EG metabolism. Comparative proteomics between the wildtype and ΔttdR strains grown on different carbon sources revealed broad metabolic reprogramming beyond EG utilization. Notably, deletion of ttdR altered the abundance of proteins involved in amino acid metabolism, fatty acid metabolism, and polyhydroxyalkanoate (PHA) metabolism. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-07_04:21:44.256.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD075327 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Eugene Dillon |
| SpeciesList | scientific name: Pseudomonas umsongensis; NCBI TaxID: NEWT:198618; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-06 10:15:00 | ID requested | |
| ⏵ 1 | 2026-09-07 04:21:45 | announced |
Publication List
| 10.6019/PXD075327; |
| 10.1007/s00253-026-13865-3; |
| Um J, Balusamy K, Wierckx N, O'Connor KE, Narancic T, and polyhydroxyalkanoate (PHA) metabolism in Pseudomonas umsongensis GO16. Appl Microbiol Biotechnol, 110(1):(2026) [pubmed] |
Keyword List
| submitter keyword: Pseudomonas umsongensis GO16 |
| Terephthalic acid |
| Glucose |
| LysR-type transcriptional regulator |
| Polyhydroxyalkanoates |
Contact List
| Tanja Narancic | |
|---|---|
| contact affiliation | Professor in Microbiology and Biochemistry School of Biomolecular and Biomedical Science https://www.ucd.ie/sbbs/ BiOrbic https://biorbic.com UCD O'Brien Centre for Science 4th Floor, room E4.09 University College Dublin Belfield D4, Ireland |
| contact email | tanja.narancic@ucd.ie |
| lab head | |
| Eugene Dillon | |
| contact affiliation | UCD |
| contact email | eugene.dillon@ucd.ie |
| dataset submitter | |
Full Dataset Link List
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| PRIDE project URI |
Repository Record List
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