⮝ Full datasets listing
PXD075246
PXD075246 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Maternal immune activation perturbs intestinal niche through microbial glycerophospholipids and drives offspring behavioral abnormalities |
| Description | Using a mouse MIA model induced by prenatal exposure to Toxoplasma gondii soluble tachyzoite antigen (STAg), we reveal that maternal gut dysbiosis, characterized by increased Firmicutes and Actinobacteria, drives offspring behavioral deficits. This dysbiosis disrupts intestinal barrier integrity and induces metabolic and inflammatory dysregulation, characterized by elevated M1 macrophages and IL-6, alongside a pronounced accumulation of the glycerophospholipid. metabolite |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-04 |
| AnnouncementXML | Submission_2026-03-04_19:29:52.868.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yu Zhang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | mass spectrometer |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-04 19:29:38 | ID requested | |
| ⏵ 1 | 2026-03-04 19:29:53 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Maternal immune activation, Gut microbiota,Behavioral abnormalities |
Contact List
| Zhipeng Xu | |
|---|---|
| contact affiliation | Nanjing Medical University |
| contact email | zhipengxu@njmu.edu.cn |
| lab head | |
| Yu Zhang | |
| contact affiliation | Nanjing Medical University |
| contact email | 715034589@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
