PXD075204

PXD075204 is an original dataset announced via ProteomeXchange.

Title	Cysteine Redox proteomics of PDIA6 over-expressing skeletal muscle
Description	To investigate the role of PDIA6 on changes to specific cysteine residues with altered redox status and insulin senstivity, we overexpressed either GFP control or FLAG-PDIA6 throughout the musculature of 4-day old male C57BL/6J mice via intraperitoneal injection with MyoAAV (Fig. 5F). At 8 weeks of age, mice were placed on a HFD for 12 weeks to induce insulin resistance. Muscle lysates were were labelled with iodoTMT and analysed by LC-MS/MS
HostingRepository	PRIDE
AnnounceDate	2026-05-29
AnnouncementXML	Submission_2026-05-28_18:17:01.220.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Benjamin Parker
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-04 04:11:37	ID requested
⏵ 1	2026-05-28 18:17:01	announced

Dataset with its publication pending

submitter keyword: PDIA6,Iodo-TMT

Benjamin Parker
contact affiliation	The University of Melbourne
contact email	ben.parker@unimelb.edu.au
lab head
Benjamin Parker
contact affiliation	The University of Melbourne
contact email	ben.parker@unimelb.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD075204

PRIDE project URI

• PRIDE
  1. PXD075204
     1. Label: PRIDE project
     2. Name: Cysteine Redox proteomics of PDIA6 over-expressing skeletal muscle