PXD075200 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Synthesis of guanylylated peptides derived from norovirus VPg as molecular tools for studying norovirus replication C4PR_LIV |
| Description | Norovirus, a member of the Caliciviridae family, is a positive-sense single-stranded RNA (+ssRNA) virus and a leading cause of acute gastroenteritis worldwide, especially affecting young children and the elderly. Due to a lack of specific treatment, norovirus infection causes 200,000 deaths each year and imposes an economic burden exceeding $60 billion. To address this challenge and develop medicines and diagnostics, further research into norovirus reproduction is needed. Norovirus uses a nucleotidylated protein, known as VPg (viral protein genome-linked), to initiate genome replication, by acting as a replication primer. The genomic RNA of norovirus is linked by a phosphodiester bond between the 5’-terminal guanosine (norovirus) and the phenolic oxygen of a tyrosine residue (Y27 for norovirus). In this work we demonstrate the synthesis of peptides derived from guanylylated norovirus VPg and their use in proteomic studies of norovirus replication. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-17 |
| AnnouncementXML | Submission_2026-08-17_00:31:31.740.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Leandro Xavier Neves |
| SpeciesList | scientific name: Murine norovirus; NCBI TaxID: NEWT:357231; |
| ModificationList | guanylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-04 03:30:06 | ID requested | |
| ⏵ 1 | 2026-08-17 00:31:32 | announced | |
Publication List
Keyword List
| submitter keyword: VPg, post-translational modification, phosphoguanosine,norovirus, nucleotidylation |
Contact List
| Ed Emmott |
|---|
| contact affiliation | Centre for Proteome Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK |
| contact email | E.Emmott@liverpool.ac.uk |
| lab head | |
| Leandro Xavier Neves |
|---|
| contact affiliation | Centre for Proteome Research, Department of Biochemistry, Cell & Systems Biology, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Liverpool, UK |
| contact email | leandroxneves@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD075200
- Label: PRIDE project
- Name: Synthesis of guanylylated peptides derived from norovirus VPg as molecular tools for studying norovirus replication C4PR_LIV
