PXD075119

PXD075119 is an original dataset announced via ProteomeXchange.

Title	TurboID-based proximity labeling to identify BRD4 and MEF2C co-interacted proteins
Description	Our studies suggest that BRD4 plays a critical role in muscle fiber-type regulation, yet the molecular mechanisms by which BRD4 cooperates with MEF2 to control muscle gene expression remain incompletely understood. To identify potential bridging factors that facilitate BRD4-MEF2 interaction, unbiased TurboID-based proximity labeling was employed to map BRD4- and MEF2-associated proteins. Comparative analysis of the BRD4- and MEF2C-TurboID proximity interactomes revealed that CHD4, a core component of the NuRD chromatin-remodeling complex, was identified as a prominent candidate. Functional protein association networks analysis indicated that these shared proteins are related to chromatin organization and transcriptional regulation.
HostingRepository	iProX
AnnounceDate	2026-03-02
AnnouncementXML	Submission_2026-03-02_17:46:43.514.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Linru Shen
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-02 17:45:33	ID requested
⏵ 1	2026-03-02 17:46:44	announced

Dataset with its publication pending

submitter keyword: BRD4,Turbo-ID,Human

Lei Fang
contact affiliation	Nanjing University
contact email	502024350026@smail.nju.edu.cn
lab head
Linru Shen
contact affiliation	Nanjing University
contact email	2959042161@qq.com
dataset submitter

iProX dataset URI