⮝ Full datasets listing
PXD075116
PXD075116 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation |
| Description | CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-03 |
| AnnouncementXML | Submission_2026-03-03_01:21:21.995.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Leixi Cao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue |
| Instrument | Q Exactive HF-X; timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-02 17:40:14 | ID requested | |
| ⏵ 1 | 2026-03-03 01:21:22 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: CHKA, PML, WIPI2 |
Contact List
| Mian Wu | |
|---|---|
| contact affiliation | Zhengzhou University, Zhengzhou University People's Hospital, Translational Medicine Research Center |
| contact email | wumian@ustc.edu.cn |
| lab head | |
| Leixi Cao | |
| contact affiliation | Zhengzhou University, Zhengzhou University People's Hospital, Translational Medicine Research Center |
| contact email | 1585529834@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
