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PXD075074
PXD075074 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Synthesis of guanylylated peptides derived from norovirus VPg as molecular tools for studying norovirus replication C4PR_LIV |
| Description | Norovirus, a member of the Caliciviridae family, is a positive-sense single-stranded RNA (+ssRNA) virus and a leading cause of acute gastroenteritis worldwide, especially affecting young children and the elderly. Due to a lack of specific treatment, norovirus infection causes 200,000 deaths each year and imposes an economic burden exceeding $60 billion. To address this challenge and develop medicines and diagnostics, further research into norovirus reproduction is needed. Norovirus uses a nucleotidylated protein, known as VPg (viral protein genome-linked), to initiate genome replication, by acting as a replication primer. The genomic RNA of norovirus is linked by a phosphodiester bond between the 5’-terminal guanosine (norovirus) and the phenolic oxygen of a tyrosine residue (Y27 for norovirus). In this work we demonstrate the synthesis of peptides derived from guanylylated norovirus VPg and their use in proteomic studies of norovirus replication. |
| HostingRepository | PanoramaPublic |
| AnnounceDate | 2026-08-11 |
| AnnouncementXML | Submission_2026-08-11_23:27:50.409.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | supported by repository but incomplete data and/or metadata |
| PrimarySubmitter | Leandro Neves |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Murine norovirus; NCBI TaxID: 357231; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-01 23:03:49 | ID requested | |
| ⏵ 1 | 2026-08-11 23:27:50 | announced |
Publication List
| Bob van Puffelen, Leandro Xavier Neves, Roy Steneker, Nico Meeuwenoord, Edward Emmott, Dmitri Viktorovitsj Filippov |
| Synthesis of a guanylylated peptide derived from norovirus VPg as a molecular tool for studying norovirus replication. RSC Chem. Biol. 2026 |
| https://doi.org/10.1039/D6CB00092D |
Keyword List
| submitter keyword: norovirus, VPg, nucleotidylation, post-translational modification, phosphoguanosine |
Contact List
| Leandro Neves | |
|---|---|
| contact affiliation | Centre for Proteome Research, Dept. Biochemistry & Systems Biology, University of Liverpool, Liverpool, UK |
| contact email | leandroxneves@gmail.com |
| lab head | |
| Leandro Neves | |
| contact affiliation | Centre for Proteome Research, Dept. Biochemistry & Systems Biology, University of Liverpool, Liverpool, UK |
| contact email | leandroxneves@gmail.com |
| dataset submitter | |
Full Dataset Link List
| Panorama Public dataset URI |
