PXD075036

PXD075036 is an original dataset announced via ProteomeXchange.

Title	Proteomics Analysis of Mycoplasma pneumoniaepneumonia (MPP) Patients
Description	Background The community-acquired respiratory distress syndrome toxin (CARDS), a key exotoxin produced by Mycoplasma pneumoniae, can induce cytopathology. M. pneumoniae pneumonia (MPP) is characterized by ciliary ultrastructural abnormalities. The effect and mechanism of CARDS on ciliary function remain to be fully elucidated. Methods We collected bronchoalveolar lavage fluid (BALF) and analysed the differences in proteomics between patients with MPP and those with other infectious diseases using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Findings We found that ciliary FMRP was down-regulated in BALF from patients with MPP. Together, our findings provide mechanistic insights into understanding the pathogenic mechanisms of CARDS on ciliary function and targeting ciliary FMRP signalling may be a potential therapeutic strategy for treating M. pneumoniae infection.
HostingRepository	iProX
AnnounceDate	2026-02-28
AnnouncementXML	Submission_2026-04-15_01:26:58.670.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jieqiong Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-28 00:11:24	ID requested
⏵ 1	2026-04-15 01:26:59	announced

Dataset with its publication pending

submitter keyword: Mycoplasma pneumoniaepneumonia, Proteomics, Pathogenesis

Jieqiong Li
contact affiliation	Beijing Chaoyang Hospital,Capital Medical University
contact email	jieqiongli2010@163.com
lab head
Jieqiong Li
contact affiliation	Beijing Chaoyang Hospital,Capital Medical University
contact email	jieqiongli2010@163.com
dataset submitter

iProX dataset URI