PXD074961 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | 4D-DIA proteomic analysis of SMT-induced cytotoxicity in B16F10 mouse melanoma cells |
| Description | This dataset contains a 4D-DIA proteomic analysis of B16F10 mouse melanoma cells treated with SMT (SM@CMC-KP101). B16F10 cells were divided into two groups: a PBS control group and an SMT treatment group. After drug exposure, cellular proteins were extracted, digested and analyzed by LC-MS/MS using a Q Exactive HF mass spectrometer. The aim of this study is to identify differentially expressed proteins and perturbed pathways associated with the cytotoxic and anti-tumor effects of SMT on melanoma cells, providing insights into its molecular mechanisms of tumor cell killing. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-02 |
| AnnouncementXML | Submission_2026-04-02_09:30:29.446.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | lihao Ji |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF; Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-26 15:41:24 | ID requested | |
| ⏵ 1 | 2026-04-02 09:30:29 | announced | |
Publication List
Keyword List
| submitter keyword: proteomics,B16F10, SMT, mouse melanoma, SM@CMC-KP101, 4D-DIA, quantitative proteomics, LC-MS/MS |
Contact List
| Wei wei |
|---|
| contact affiliation | State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Life Sciences, Nanjing University, Nanjing 210093, P. R. China. |
| contact email | weiwei@nju.edu.cn |
| lab head | |
| lihao Ji |
|---|
| contact affiliation | nanjing university |
| contact email | lihaojji@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD074961 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074961
- Label: PRIDE project
- Name: 4D-DIA proteomic analysis of SMT-induced cytotoxicity in B16F10 mouse melanoma cells
