⮝ Full datasets listing
PXD074923
PXD074923 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multi-Omics Analysis Reveals Molecular Disruption in Mouse Testes Following Cumulative heat stress |
| Description | Rising global temperatures threaten male fertility, yet the molecular mechanisms by which heat stress disrupts spermatogenesis remain incompletely understood. We employed an integrative multi-omics approach incorporating transcriptomics, proteomics, and metabolomics to examine the impact of sub-lethal HS (Heat stress) on the testes and spermatozoa of male mice. Our results demonstrated that HS significantly diminished sperm motility and compromised the architecture of seminiferous tubules. Multi-omics integration demonstrated a synchronized downregulation of pathways regulating glycolysis, flagellar assembly, and antioxidant defense, as well as disruptions in steroid hormone production and redox equilibrium. These systemic changes collectively contribute to defective energy metabolism, aberrant sperm viability, and diminished tolerance to oxidative stress, ultimately leading to reduced reproductive potential. This study provides an integrated multi-omics view of heat stress–associated molecular disruptions in mouse testes and highlights convergent pathways linked to impaired male reproductive function |
| HostingRepository | iProX |
| AnnounceDate | 2026-02-26 |
| AnnouncementXML | Submission_2026-02-25_17:09:47.418.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Muhammad Ammar Baibr |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-25 17:09:15 | ID requested | |
| ⏵ 1 | 2026-02-25 17:09:47 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Heat stress, Multi-omics integration, Sperm motility, Climate-induced infertility, CASA, Testicular proteome, Metabolic reprogramming |
Contact List
| Guozhi Yu | |
|---|---|
| contact affiliation | Sichuan Agricultural University |
| contact email | guozhi.yu@sicau.edu.cn |
| lab head | |
| Muhammad Ammar Baibr | |
| contact affiliation | Sichuan Agricultural University |
| contact email | ammarbaibrus0@gmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
