⮝ Full datasets listing
PXD074921
PXD074921 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | RBM11 drives malignant progression of bladder cancer by regulating GNPDA1-PKM2 axis |
| Description | This study investigated the biological functions and molecular mechanisms of RNA-binding motif protein 11 (RBM11) in bladder cancer (BCa) progression. Integrated bioinformatics analysis of the TCGA database and validation in clinical tissues revealed that RBM11 is significantly upregulated in BCa and positively correlated with advanced tumor stage, poor prognosis, and epithelial-mesenchymal transition (EMT). RBM11 knockdown effectively suppressed migration, invasion, proliferation, and chemoresistance of BCa cells, whereas RBM11 overexpression produced opposite effects. Mechanistically, RBM11 promotes GNPDA1 expression by regulating alternative splicing of GNPDA. Furthermore, GNPDA1 directly interacts with PKM2 and inhibits its ubiquitin-proteasome-mediated degradation, thereby stabilizing PKM2 protein levels, enhancing glycolysis, and promoting malignant progression of BCa. Collectively, these findings indicate that RBM11 drives malignant progression of BCa through the GNPDA1-PKM2 axis, enhancing glucose metabolism reprogramming and EMT process, suggesting that RBM11 may be a potential therapeutic target for BCa. |
| HostingRepository | iProX |
| AnnounceDate | 2026-02-26 |
| AnnouncementXML | Submission_2026-02-25_17:06:26.900.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hang Tong |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-25 17:05:56 | ID requested | |
| ⏵ 1 | 2026-02-25 17:06:27 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: bladder cancer, RBM11, epithelial-mesenchymal transformation, GNPDA1, PKM2, glycolysis |
Contact List
| Weiyang He | |
|---|---|
| contact affiliation | The First Affiliated Hospital of Chongqing Medical University |
| contact email | weiyang1262020@126.com |
| lab head | |
| Hang Tong | |
| contact affiliation | The First Affiliated Hospital of Chongqing Medical University |
| contact email | tonghang1122@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
