PXD074893

PXD074893 is an original dataset announced via ProteomeXchange.

Title	Mouse serum DIA-based proteomic profiling after 1-day or 7-day daily heat stress exposure
Description	This project profiles heat stress (HS)-induced alterations in the mouse serum proteome to identify circulating proteins that are consistently regulated by HS. Mice were assigned to three groups: PF (pair-fed control at room temperature, RT), HS1D (daily HS for 1 day, 6 h/day), and HS7D (daily HS for 7 consecutive days, 6 h/day). The PF group serves as the shared control and was collected at the same time point as the HS1D group (RT, 1 day), providing a reference for HS-associated changes. The primary objective is to identify overlapping proteomic changes in both HS groups relative to PF, highlighting robust HS-responsive circulating proteins.
HostingRepository	PRIDE
AnnounceDate	2026-04-28
AnnouncementXML	Submission_2026-04-27_22:10:31.699.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xu Feng
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-25 05:23:31	ID requested
⏵ 1	2026-04-27 22:10:32	announced

Zhou HY, Feng X, Wen J, Xiao Y, Wang LW, Chen LY, Xie GQ, Zhao JJ, Huang Y, Luo XH, A skin-hypothalamus axis couples heat stress and metabolic dysfunction. Cell, ():(2026) [pubmed]

10.1016/j.cell.2026.03.045;

submitter keyword: mouse serum

DIA proteomics

Xiang-Hang Luo
contact affiliation	Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University
contact email	xianghangluo@sina.com
lab head
Xu Feng
contact affiliation	Xiangya Hospital of Central South University
contact email	fengxures@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD074893

PRIDE project URI

• PRIDE
  1. PXD074893
     1. Label: PRIDE project
     2. Name: Mouse serum DIA-based proteomic profiling after 1-day or 7-day daily heat stress exposure