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PXD074854
PXD074854 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Plasmodium falciparum ApiAP2 transcription factor PfAP2-V controls parasite proliferation and virulence in intra-erythrocytic developmental cycle |
| Description | Malaria pathogenesis, encompassing parasite invasion, egress, and antigenic variation, relies on the coordinated activity of numerous proteins, yet their molecular regulatory mechanisms remain poorly understood. Here, we define the role of PfAP2-V, a critical AP2 transcription factor in Plasmodium falciparum, during intra-erythrocytic developmental cycle. PfAP2-V displayed two distinct peaks of expression and was critical for parasite proliferation, invasion, and the regulation of virulence-associated genes. Inducible knockdown of PfAP2-V reduced parasitemia by blocking trophozoite development, which was associated with downregulated phosphorylation of virulence-associated proteins. Furthermore, PfAP2-V knockdown reduced PfEMP1 expression, impairing the adhesion of infected red blood cells to endothelial receptors. Genome-wide chromosome conformation capture and chromatin immunoprecipitation sequencing analyses revealed that PfAP2-V knockdown altered chromatin interactions and accessibility, disrupting the regulation of antigenic variant genes. These findings establish PfAP2-V as a key transcriptional regulator at distinct stages of the intra-erythrocytic cycle. |
| HostingRepository | iProX |
| AnnounceDate | 2026-02-23 |
| AnnouncementXML | Submission_2026-02-24_23:16:17.692.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yanxin Zhang |
| SpeciesList | scientific name: Plasmodium falciparum Tanzania (2000708); NCBI TaxID: 1036725; |
| ModificationList | phosphorylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-24 23:16:01 | ID requested | |
| ⏵ 1 | 2026-02-24 23:16:18 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ApiAP2 |
Contact List
| Yanxin Zhang | |
|---|---|
| contact affiliation | Shenyang Agricultural University |
| contact email | 1186701128@qq.com |
| lab head | |
| Yanxin Zhang | |
| contact affiliation | Shenyang Agricultural University |
| contact email | 1186701128@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
