PXD074843 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Low intrinsic agonism and balanced pathway modulation distinguish an M1 muscarinic receptor positive allosteric modulator lacking cholinergic adverse effects |
| Description | Positive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (mAChR) have progressed into clinical trials for cognitive disorders, such as Alzheimer’s disease and schizophrenia. This work provides a mechanistic framework for differentiating M1 PAM pharmacology beyond intrinsic agonism alone and may inform the design of safer M1-targeted therapeutics. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-06 |
| AnnouncementXML | Submission_2026-07-05_17:00:09.779.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Laura Dagley |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-24 22:35:54 | ID requested | |
| 1 | 2026-07-05 16:37:40 | announced | |
| ⏵ 2 | 2026-07-05 17:00:10 | announced | 2026-07-06: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: signalling pathways, schizophrenia, cognition, Alzheimer's disease, M1 muscarinic acetylcholine receptors,Allosteric modulation, biased allosterism |
Contact List
| John Scott |
|---|
| contact affiliation | Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia |
| contact email | john.scott@monash.edu |
| lab head | |
| Laura Dagley |
|---|
| contact affiliation | WEHI |
| contact email | dagley.l@wehi.edu.au |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD074843 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074843
- Label: PRIDE project
- Name: Low intrinsic agonism and balanced pathway modulation distinguish an M1 muscarinic receptor positive allosteric modulator lacking cholinergic adverse effects
