PXD074824

PXD074824 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Phenotypic signature of USPl7L2
Description	The deubiquitinase USP17 was previously shown to regulate KLF4 expression in hepatocellular carcinomas. The KLF4 transcription factor is a major regulator of the phenotypic response of vascular smooth muscle cells, enabling their polarization toward a synthetic phenotype observed in several aortic remodeling diseases, including aneurysms and atherosclerosis. The aim here was therefore to reduce USP17 expression in primary-cultured human aortic smooth muscle cells and to verify their fate (contractile or synthetic phenotype) through proteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2026-02-25
AnnouncementXML	Submission_2026-02-25_06:01:44.882.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eric Bonneil
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	LTQ FT

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-24 18:20:14	ID requested
⏵ 1	2026-02-25 06:01:45	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: vascular smooth muscle cells, phenotypic switch, abdominal aortic aneurysm, KLF4,USP17

submitter keyword: vascular smooth muscle cells, phenotypic switch, abdominal aortic aneurysm, KLF4,USP17

Contact List

Marc Servant
contact affiliation	Université de Montréal
contact email	marc.servant@umontreal.ca
lab head
Eric Bonneil
contact affiliation	Proteomic Platform
contact email	eric.bonneil@umontreal.ca
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD074824
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD074824

PRIDE project URI

Repository Record List

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