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PXD074803
PXD074803 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification and stratification of the human urinary glycopeptides by LC–MS with age/sex-insensitive reference ranges |
| Description | advances in LC-MS have enabled broad profiling of urinary N-glycopeptides, yet normal demographic variation remains insufficiently defined. This gap complicates biomarker studies, as physiological differences can be mistaken for disease signals. This study aimed to characterize age and sex effects on intact urinary N-glycopeptides in healthy adults and construct a demographic reference resource suitable for biomarker development. Methods: Urinary N-glycopeptides from 108 healthy adults (aged 20 to 60 years) were profiled using a standardized LC MS workflow following hydrophilic interaction liquid chromatography enrichment. Intact N glycopeptides were quantified at the protein, site, glycan, and peptide levels. Covariate-adjusted principal component analysis and change point detection were applied to characterize demographic structure. Glycopeptides not associated with age or sex were identified and used to construct a demographic reference set with defined quantitative ranges. |
| HostingRepository | iProX |
| AnnounceDate | 2026-02-12 |
| AnnouncementXML | Submission_2026-08-13_20:06:41.654.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiayu Liu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-24 17:00:43 | ID requested | |
| ⏵ 1 | 2026-08-13 20:06:42 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: N-glycopeptides, Urine Glycosylation, age-insensitive, sex-insensitive, LC-MS, proteomics |
Contact List
| Mianyang Li | |
|---|---|
| contact affiliation | Chinese PLA General Hospital |
| contact email | limianyang301@163.com |
| lab head | |
| Jiayu Liu | |
| contact affiliation | Chinese PLA General Hospital |
| contact email | shelly_7@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
