⮝ Full datasets listing
PXD074799
PXD074799 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multimodal Antidepressant Actions of Schisanhenol Through 5-LOX Modulation, Neuroinflammation Suppression, and Synaptic Repair |
| Description | This project focuses on the core research direction of \"Wuweizi phenol exerting multimodal antidepressant effects by regulating 5-lipoxygenase (5-LOX), inhibiting neuroinflammation, and repairing synaptic function\". It employs quantitative proteomics technology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS), using a mouse model of depression-like behavior induced by chronic social defeat stress (Chronic Social Defeat Stress, CSDS) as the research object. The project systematically analyzes the differences in protein expression profiles in the prefrontal cortex (Prefrontal Cortex, PFC) of mice in the model group, normal control group, and Wuweizi phenol intervention group. The core goal is to screen key differentially expressed proteins (Differentially Expressed Proteins, DEPs) associated with CSDS-induced depression-like behaviors, 5-LOX signaling pathway regulation, neuroinflammation, and synaptic damage/repair. It aims to deeply explore the core signaling pathways and molecular regulatory networks involved in DEPs, clarify the protein-level mechanism by which Wuweizi phenol exerts antidepressant effects, and simultaneously provide solid proteomic data support and scientific theoretical basis for elucidating the pathogenesis of depression, screening potential diagnostic markers, and developing antidepressant drugs targeting 5-LOX regulation, neuroinflammation inhibition, or synaptic repair. |
| HostingRepository | iProX |
| AnnounceDate | 2026-02-12 |
| AnnouncementXML | Submission_2026-02-24_16:43:15.724.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yi Zhang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-24 16:42:52 | ID requested | |
| ⏵ 1 | 2026-02-24 16:43:16 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: csds, Neuroinflammation, Synaptic Repair |
Contact List
| Jing Du | |
|---|---|
| contact affiliation | Capital Medical University |
| contact email | dujing2020@ccmu.edu.cn |
| lab head | |
| Yi Zhang | |
| contact affiliation | Capital Medical University |
| contact email | zhangyi19930423@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
