PXD074780

PXD074780 is an original dataset announced via ProteomeXchange.

Title	An integrated proteome and phospho-proteome approach to study BPA toxicity on placenta.
Description	The environmental exposure of various Endocrine disrupting chemicals (EDCs) like Bisphenol-A (BPA), can affect human health by inducing hormonal imbalance important for physiological homeostasis. Pregnant females are more susceptible for BPA mediated toxicity. BPA can reach maternal circulation by ingestion, inhalation or dermal contact from plastic goods or everyday house-hold items, which then crosses the placental barrier and imparts damage on trophoblast cells. This BPA mediated cellular injury directly alters feto-maternal homeostasis disrupting fetal development and growth. The feto-maternal disruption is induced by impaired cellular signaling in placenta, which can also affect the post translational protein phosphorylation patterns. Therefore, this study explores the dynamic proteome change upon BPA exposure which also affects the kinase associated phospho-signatures in both early trimester trophoblast cells and murine placenta. This finding provides an important insight on the mechanism of altered phosphorylation which may drive the BPA associated toxicity in placenta and trophoblast cells contributing towards placenta mediated reproductive disorders.
HostingRepository	PRIDE
AnnounceDate	2026-07-14
AnnouncementXML	Submission_2026-07-14_04:18:24.901.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	TUSHAR KANTI MAITI
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	ZenoTOF 7600

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-24 13:20:43	ID requested
⏵ 1	2026-07-14 04:18:25	announced

10.1021/ACS.CHEMRESTOX.6C00191;

submitter keyword: Bisphenol-A,Placenta, Extra-villous trophoblast, zenoSWATH, Ecotoxico-proteomics, Phosphoproteome

Dr. Tushar Kanti Maiti
contact affiliation	Professor Regional Centre for Biotechnology NCR Biotech Science Cluster 3rd Milestone, Faridabad-Gurgaon Expressway Faridabad-121001, Haryana INDIA
contact email	tkmaiti@rcb.res.in
lab head
TUSHAR KANTI MAITI
contact affiliation	Regional Centre for Biotechnology
contact email	tkmaiti@rcb.res.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD074780

PRIDE project URI

• PRIDE
  1. PXD074780
     1. Label: PRIDE project
     2. Name: An integrated proteome and phospho-proteome approach to study BPA toxicity on placenta.