PXD074754

PXD074754 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Characterization of Sericin-Capped Gold Nanoparticles as a Tentative Anti-microbial Agent in Urinary Catheter
Description	Catheter-associated urinary tract infection (CAUTI) is the most common healthcare-associated infection. The increasing rates of antibiotic resistance in CAUTI need the development of alternative therapeutic approaches. Gold nanoparticles (AuNPs) are particularly appealing due to their inherent inertness and low cytotoxicity, making them ideal for a wide range of biological and antibacterial applications. Sericin protein, derived from silkworm cocoons (Bombyx mori), is regarded as a byproduct but has found value in biomedical applications due to its processability, biocompatibility, and biological inertness. However, the molecular mechanisms underlying the antibacterial properties of sericin-conjugated AuNPs (AuNP-sericin) in human urine remain uncharacterized, and guidance for their appropriate application in catheters is limited. Forty catheter-associated urine samples were collected for urinalysis and bound to AuNP-sericin for a molecular mechanism study using proteomics. AuNP-sericin accumulation on microorganism cell surfaces via electrostatic interactions, as evidenced by transmission electron microscope. This situation may disrupt membranes, block nutrient access, and thus interfere with microbial metabolic pathways. Proteomics investigation confirmed that AuNP-sericin can restrict microbial growth by trapping their membranes, interfering with translation and metabolism. These qualities may inhibit colonization and biofilm development, lowering antibiotic use and CAUTI rates, which are a leading cause of hospitalization.
HostingRepository	jPOST
AnnounceDate	2026-07-13
AnnouncementXML	Submission_2026-07-13_02:00:47.840.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dr.Wararat Chiangjong
SpeciesList	scientific name: Bacteria; NCBI TaxID: 2;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrument	TripleTOF 6600+

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-23 22:03:10	ID requested
⏵ 1	2026-07-13 02:00:48	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: AuNP-sericin, gold nanoparticle, catheter-associated urinary tract infection, antibiotic resistance, microorganism

submitter keyword: AuNP-sericin, gold nanoparticle, catheter-associated urinary tract infection, antibiotic resistance, microorganism

Contact List

Pokket Sirisreetreerux
lab head
Dr.Wararat Chiangjong
contact affiliation	Mahidol University
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004430/