PXD074635

PXD074635 is an original dataset announced via ProteomeXchange.

Title	Integrated tissue and urinary proteomic analysis of prostate cancer and MRI visibility
Description	This study aimed to explore proteomic alterations associated with prostate cancer presence, aggressiveness, and MRI visibility. Tissue and preoperative urine samples were collected from patients diagnosed with benign prostatic hyperplasia, indolent prostate cancer, and clinically significant prostate cancer, including MRI-visible and MRI-non-visible cases. Proteins were extracted, digested using standard trypsin-based protocols, and analyzed by nanoLC–MS/MS using a high-resolution mass spectrometry platform operating in data-independent acquisition (DIA) mode. Protein identification and quantification were performed using established computational workflows. Statistical analyses were conducted to identify differentially expressed proteins across the clinical groups. This dataset includes raw mass spectrometry files, processed identification and quantification results, and supporting files necessary for data interpretation.
HostingRepository	PRIDE
AnnounceDate	2026-04-06
AnnouncementXML	Submission_2026-04-05_16:10:45.970.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ana Blanca
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF fleX

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-19 11:35:36	ID requested
⏵ 1	2026-04-05 16:10:47	announced

10.3390/life16030383;

Blanca A, Morillo AC, Lopez-Beltran A, Lendinez Cano G, Medina RA, Chamorro Castillo L, L, ó, pez Ruiz D, Chicano-Galvez E, Campos Hern, á, ndez JP, G, ó, mez G, ó, mez E, Integrated Urinary and Tissue Proteomic Signatures Reveal Core and Progression Biomarkers in MRI-Visible and MRI-Non-Visible Prostate Cancer. Life (Basel), 16(3):(2026) [pubmed]

submitter keyword: Prostate cancer

Proteomics

Urin

Tissue

Mass spectrometry, DIA

Biomarker discovery

Enrique Gomez Gomez
contact affiliation	Reina Sofia Hospital. University of Cordoba. Maimonides Institute for Biomedical Research of Cordoba
contact email	enriquegomezgomez@yahoo.es
lab head
Ana Blanca
contact affiliation	Cordoba University
contact email	b62blpea@uco.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD074635

PRIDE project URI

• PRIDE
  1. PXD074635
     1. Label: PRIDE project
     2. Name: Integrated tissue and urinary proteomic analysis of prostate cancer and MRI visibility