PXD074587 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | DIA-based Proteomic analysis of human islets with treatment of a PERK inhibitor |
| Description | Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucidate the beta-cell enhancing mechanisms of PERK attenuation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-29 |
| AnnouncementXML | Submission_2026-06-28_16:25:46.828.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Dohyun Han |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-18 06:42:37 | ID requested | |
| ⏵ 1 | 2026-06-28 16:25:47 | announced | |
Publication List
| 10.1016/j.mcpro.2026.101588; |
| Park YS, Yun S, Sim MS, An EJ, Lee J, Ha EH, Jang JY, Kwon W, Han D, Jung HS, Proteomic Analysis on Human Islets Suggests Nucleocytoplasmic Transport as a Mechanism of PERK Attenuation Effects in Diabetes. Mol Cell Proteomics, 25(6):101588(2026) [pubmed] |
Keyword List
| submitter keyword: Human, Islets, DIA, PERK inhibitor |
Contact List
| Dohyun Han |
|---|
| contact affiliation | Proteomics and Metabolomics Core Facility, Biomedical Research Institute, Seoul National University Hospital |
| contact email | hdh03@snu.ac.kr |
| lab head | |
| Dohyun Han |
|---|
| contact affiliation | Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital |
| contact email | hdh03@snu.ac.kr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD074587 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074587
- Label: PRIDE project
- Name: DIA-based Proteomic analysis of human islets with treatment of a PERK inhibitor
