PXD074516 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Hyaluronan and gellan nanohydrogels exhibit an unexpected activity in hampering Staphylococcus epidermidis biofilm |
| Description | In clinical settings, the intensive use of antibiotics, particularly in intensive care settings, leads to a significant increase in the number of bacterial species that are resistant to treatment. In this context, biofilm is a crucial virulence factor that enable bacteria to persist within the host, often resulting in the need for extensive antibiotic treatment. Staphylococcus epidermidis, a notable nosocomial pathogen, poses a risk to vulnerable patients due to its ability to form biofilms on indwelling medical devices and its high resistance to antibiotic therapy. For this purpose, investigating alternative strategies that target the virulence of pathogens could offer a promising alternative strategy. In this study, we analyzed innovative polymeric materials, such as polysaccharide-based nanohydrogels, for their potential application contrasting S. epidermidis monospecies biofilm on the surfaces of materials most employed in medical devices. These nanohydrogels were found to be effective in eradicating the biofilm matrix and preventing bacterial adhesion. Additionally, the treatment with hyaluronan-based nanohydrogels altered the surface protein profile of S. epidermidis, leading to the disappearance of AtlE, the primary autolysin involved in biofilm formation, suggesting a potential mechanism of action for these nanogels. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-30 |
| AnnouncementXML | Submission_2026-03-29_16:06:47.745.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Marco Morelli |
| SpeciesList | scientific name: Staphylococcus epidermidis; NCBI TaxID: NEWT:1282; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-16 06:38:03 | ID requested | |
| ⏵ 1 | 2026-03-29 16:06:48 | announced | |
Publication List
| 10.1016/j.jconrel.2026.114861; |
| Pietrella A, Paris I, Migliorini C, Morelli M, Carpentieri A, Matricardi P, Di Meo C, Papa R, Hyaluronan and gellan nanohydrogels exhibit an unexpected activity in hampering Staphylococcus epidermidis biofilm. J Control Release, 394():114861(2026) [pubmed] |
Keyword List
| submitter keyword: Nanohydrogels |
| Staphylococcus epidermidis |
| Anti-biofilm |
| Polysaccharides |
| Hyaluronic Acid |
| Gellan gum; |
Contact List
| Andrea Carpentieri |
|---|
| contact affiliation | Department of Chemical Sciences, University of Naples Federico II, Strada Comunale Cinthia, 26 80126 Naples, Italy. |
| contact email | acarpent@unina.it |
| lab head | |
| Marco Morelli |
|---|
| contact affiliation | Dipartimento di scienze chimiche Università Federico II di Napoli |
| contact email | marco.morelli@unina.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074516
- Label: PRIDE project
- Name: Hyaluronan and gellan nanohydrogels exhibit an unexpected activity in hampering Staphylococcus epidermidis biofilm
