PXD074503

PXD074503 is an original dataset announced via ProteomeXchange.

Title	High-risk EBV promotes immune evasion in nasopharyngeal carcinoma by upregulating HLA-DP via the encoded BALF2-HR variant
Description	Nasopharyngeal carcinoma (NPC) is prevalent in East and Southeast Asia, with genetic factors playing a significant role in its occurrence. The HLA gene region on chromosome 6 is linked to NPC susceptibility, but the mechanisms remain unclear. Epstein-Barr virus (EBV) infection is a well-established cause, with 95% of NPC patients being EBV-positive. Three key variations in the EBV genome (162215_C, 162476_C, 163364_T) in the BALF2 gene are strongly associated with NPC risk. This study finds that the high-risk BALF2 variant (BALF2-HR) upregulates HLA class II molecules, such as HLA-DP, which interacts with LAG-3 on CD8⁺ T cells, inhibiting cytokine secretion and promoting T cell exhaustion, leading to immune evasion and reduced anti-PD-1 efficacy. BALF2-HR also enhances HLA-DP transcription by binding to KPNA2 and facilitating CIITA nuclear translocation. Conjunctive immunotherapy with anti-LAG-3 and anti-PD-1 antibodies significantly improves NPC treatment. This work introduces a new therapeutic strategy for NPC and insights into infection-associated cancers.
HostingRepository	PRIDE
AnnounceDate	2026-02-17
AnnouncementXML	Submission_2026-02-16_18:49:02.000.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Xiong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-16 01:39:42	ID requested
⏵ 1	2026-02-16 18:49:02	announced

Dataset with its publication pending

submitter keyword: Nasopharyngeal carcinoma, immune evasion, BALF2, high-risk EBV subtype, HLA-DP

Wei Xiong
contact affiliation	Cancer Research Institute, Xiangya Basic Medical College, Central South University, No. 110 Xiangya Road, Kaifu District, Changsha City, Hunan Province
contact email	xiongwei@csu.edu.cn
lab head
Wei Xiong
contact affiliation	Cancer Research Institute, School of Basic Medical Science, Central South University
contact email	xiongwei@csu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD074503

PRIDE project URI

• PRIDE
  1. PXD074503
     1. Label: PRIDE project
     2. Name: High-risk EBV promotes immune evasion in nasopharyngeal carcinoma by upregulating HLA-DP via the encoded BALF2-HR variant