PXD074382 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis |
| Description | This study investigates how loss of the ER transporter SLC33A1 affects glutathione redox balance and protein cysteine reactivity in the endoplasmic reticulum. Oxidized cysteine reactivity profiling and whole-cell proteomics were performed in Slc33a1 knockout KPK cells and cDNA-complemented controls. Quantitative TMT-based proteomics identified increased oxidation of protein disulfide isomerases and other ER-resident proteins, indicating disruption of ER redox homeostasis and proteostasis. Additional experiments examined unfolded protein response activation and genetic interactions with ER quality-control pathways. The dataset includes cysteine reactivity profiling and unenriched proteomics data acquired by LC–MS/MS and processed using standard proteomics pipelines. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-13 |
| AnnouncementXML | Submission_2026-02-13_11:46:19.197.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shanshan Liu |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-12 02:55:24 | ID requested | |
| ⏵ 1 | 2026-02-13 11:46:19 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: glutathione, TMT proteomics,ER redox, SLC33A1, cysteine reactivity, mouse cells, LC–MS/MS |
Contact List
| Kivanc, Birsoy |
|---|
| contact affiliation | The Rockefeller University |
| contact email | kbirsoy@rockefeller.edu |
| lab head | |
| Shanshan Liu |
|---|
| contact affiliation | The Rockefeller University |
| contact email | sliu04@rockefeller.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074382
- Label: PRIDE project
- Name: SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis
