PXD074328

PXD074328 is an original dataset announced via ProteomeXchange.

Title	Proteomic Profiling of the Prefrontal Cortex Reveals Dysregulated Mitochondria-Metabolism-Synapse Axis in a Chronic Stress-Induced Mouse Model of Depression
Description	This project aims to systematically analyze the differences in protein expression in the prefrontal cortex (Prefrontal Cortex, PFC) of Chronic Social Defeat Stress (CSDS) model mice and normal control group mice using quantitative proteomics technology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS). It will screen key differentially expressed proteins (Differentially Expressed Proteins, DEPs) associated with CSDS-induced depressive-like behaviors, explore the signaling pathways and molecular mechanisms they participate in, and provide solid proteomic data support and theoretical basis for research on the pathogenesis of depression, screening of potential diagnostic markers, and development of targeted therapeutic drugs.
HostingRepository	iProX
AnnounceDate	2026-02-11
AnnouncementXML	Submission_2026-02-10_22:57:28.478.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi Zhang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-10 22:56:11	ID requested
⏵ 1	2026-02-10 22:57:29	announced

Dataset with its publication pending

submitter keyword: CSDS, PFC, Proteomic

Jing Du
contact affiliation	Capital Medical University
contact email	dujing2020@ccmu.edu.cn
lab head
Yi Zhang
contact affiliation	Capital Medical University
contact email	zhangyi19930423@163.com
dataset submitter

iProX dataset URI