PXD074262

PXD074262 is an original dataset announced via ProteomeXchange.

Title	Effect of cancer-associated fibroblast exosomes on murine T cells
Description	We profiled how cancer associated fibroblast exosomes alter T cells in mouse breast tumor setting using mass spectrometry. Briefly, exosomes were isolated from breast cancer associated fibroblasts from the MCa-P1362 cell line and then applied to primary CD8+ T cells from BALB/c mice. After exposure for 24 hours, T cells stimulated with anti-CD3/CD28 antibodies for indicated times and were harvested and subjected to quantitative proteomic and phosphoproteomic analysis by mass spectrometry to capture changes in protein expression and signaling. Unstimulated cells and stimulated cells not exposed to exosomes were used as comparators.
HostingRepository	PRIDE
AnnounceDate	2026-03-30
AnnouncementXML	Submission_2026-03-29_16:07:06.230.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Carl White
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	phosphorylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-09 15:58:55	ID requested
⏵ 1	2026-03-29 16:07:07	announced

10.1158/2767-9764.crc-25-0259;

Jana S, Lawton M, Lei PJ, Hui H, Emili A, Jones D, Collagen-Bearing Exosomes from Breast Cancer-Associated Fibroblasts Promote T-cell Dysfunction. Cancer Res Commun, 6(3):630-647(2026) [pubmed]

submitter keyword: breast cancer, exosomes,cancer-associated fibroblasts, T cells

Dennis Jones
contact affiliation	Boston University Chobanian & Avedisian School of Medicine Department of Pathology & Laboratory Medicine
contact email	djones1@bu.edu
lab head
Carl White
contact affiliation	Oregon Health & Science University
contact email	whicarl@ohsu.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD074262
     1. Label: PRIDE project
     2. Name: Effect of cancer-associated fibroblast exosomes on murine T cells