PXD074238 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A Proteomic Profiling of Tegumental Washes in Ligula intestinalis (Cestoda) and Host Cavity Washes of Abramis brama (Leuciscidae) |
| Description | The aim of this study was to characterize the molecular interactions zone between the plerocercoid of Ligula intestinalis and its host, a common bream Abramis brama. Using HPLC-MS/MS we performed a comparative proteomic analysis of washes from the parasite surface and from the body cavity of infected and uninfected fish. We identified both parasitic and host proteins on the helminth surface, reflecting an active molecular crosstalk. Functional analysis revealed cestode-specific metabolic and signaling pathways (eg. such as proline biosynthesis and TOR signaling), including those for amino acid biosynthesis, lipid transport, and nutrient sensing. Within the body cavity of infected fish, we detected parasite-derived proteins such as immunomodulators, proteases, and metabolic enzymes. Quantitative changes in host wash proteomes indicated activation of humoral immunity alongside remodeling of proteolytic regulation. Collectively, these data reveal the molecular foundation of L. intestinalis adaptation and the dynamic host-parasite relationships in this system. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-10 |
| AnnouncementXML | Submission_2026-07-10_07:09:29.310.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Albina Tsekova |
| SpeciesList | scientific name: Abramis brama; NCBI TaxID: NEWT:38527; scientific name: Ligula intestinalis; NCBI TaxID: NEWT:94845; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-09 08:09:28 | ID requested | |
| ⏵ 1 | 2026-07-10 07:09:29 | announced | |
Publication List
Keyword List
| submitter keyword: proteomics, common bream, excretory–secretory proteins,Cestoda, host-parasite interaction |
Contact List
| Tsekova Albina |
|---|
| contact affiliation | Institute of Biology of the Karelian Research Centre of the Russian Academy of Sciences,Russia |
| contact email | kochnevaalbina@gmail.com |
| lab head | |
| Albina Tsekova |
|---|
| contact affiliation | Institute of Biology of the Karelian Research Centre of the Russian Academy of Sciences |
| contact email | kochnevaalbina@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074238
- Label: PRIDE project
- Name: A Proteomic Profiling of Tegumental Washes in Ligula intestinalis (Cestoda) and Host Cavity Washes of Abramis brama (Leuciscidae)
