⮝ Full datasets listing
PXD074228
PXD074228 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Retention-Modulating Derivatization Unlocks Full Structural Resolution of Glycerophospholipid Isomers |
| Description | The precise structural characterization of lipids is fundamental to understanding their biological roles. However, full structural resolution of complex lipids at the isomer level remains a significant challenge. Here, we propose an integrated orthogonal analysis strategy that simultaneously resolves lipid C=C bond location, C=C bond configuration, and sn-position in a single injection, enabling complete structural elucidation of glycerophospholipids at the isomer level. This method is based on the principles of simultaneous C=C bond activation and fatty acyl chain polarity difference modulation. By introducing a specific N-benzyl-aziridine structure at the double bond of fatty acyl chains, this derivatization enables C=C bond location identification based on induced characteristic fragmentation, C=C bond configuration assignment based on specific chromatographic elution order, and sn-position identification based on amplified chromatographic separation and characteristic fragmentation. Using the established |
| HostingRepository | iProX |
| AnnounceDate | 2026-02-07 |
| AnnouncementXML | Submission_2026-02-09_02:11:21.992.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuhao Han |
| SpeciesList | scientific name: Acyrthosiphon pisum; NCBI TaxID: 7029; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-09 02:11:04 | ID requested | |
| ⏵ 1 | 2026-02-09 02:11:22 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: lipidomic, lisomers, Full Structural Resolution |
Contact List
| Suming Chen | |
|---|---|
| contact affiliation | The Institute for Advanced Studies, Wuhan University |
| contact email | chensm@iccas.ac.cn |
| lab head | |
| Yuhao Han | |
| contact affiliation | The Institute for Advanced Studies, Wuhan University |
| contact email | 1171575518@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
