⮝ Full datasets listing
PXD074222
PXD074222 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Combing-triggered electrostimulation synchronizing deep delivery for enhanced androgenetic alopecia therapy |
| Description | Androgenetic alopecia (AGA) affects over 1.5 billion individuals, causing progressive hair loss with psychological and quality-of-life burdens. Current pharmacological treatment for AGA faces challenges due to systemic side effects from oral medications or limited efficacy of topical applications. Herein we developed a comb-shaped bioelectronic system, named “Detangle”, for efficient AGA treatment during daily hair combing. This system features electronic teeth embedded with height-differentiated electrodes and integrated drug-loading modules, which generate an enhanced electric field penetrating up to ~9 times deeper into hair follicle regions than conventional external application. The localized electric field synchronizes electro-stimulating hair follicles, and electro-delivering vascular endothelial growth factor A (VEGFA) encoding plasmid and steroid 5-alpha-reductase 2 (SRD5A2) targeting siRNA into follicular cells for promoting angiogenesis and suppressing androgen synthesis. Through these two synergistic mechanisms of cellular metabolism regulation, the system significantly increases hair restoration efficacy, improving the outcome from 70% to nearly 100% within one month compared to conventional treatment. The Detangle system proves safe and effective for deep tissue delivery in dermatology. |
| HostingRepository | iProX |
| AnnounceDate | 2026-02-06 |
| AnnouncementXML | Submission_2026-02-08_23:23:33.543.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Feng Liu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-08 23:22:43 | ID requested | |
| ⏵ 1 | 2026-02-08 23:23:34 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Wearable electronics, electrostimulation, drug delivery, androgenetic alopecia, hair follicle regeneration |
Contact List
| Lingqian Chang | |
|---|---|
| contact affiliation | Beihang University |
| contact email | lingqianchang@buaa.edu.cn |
| lab head | |
| Feng Liu | |
| contact affiliation | Beihang University |
| contact email | liufenglf@buaa.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
