PXD074201 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comprehensive retinal characterization of myopic guinea pigs after PI3K/AKT inhibition via data-independent acquisition on an Orbitrap Exploris 480 mass spectrometer. |
| Description | Myopia progression is driven by abnormal signaling pathways, particularly the PI3K/AKT pathway. Using a lens-induced myopia model in guinea pigs, we administered the PI3K/AKT inhibitor LY294002 via intravitreal injection and performed quantitative proteomic analysis with data-independent acquisition mass spectrometry. This study provides retinal proteomic data from normal, myopic, and drug-treated guinea pigs. It also establishes the first comprehensive retinal proteome database for guinea pig myopia, offering insights into myopia development and the role of the PI3K/AKT pathway in its progression. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-23 |
| AnnouncementXML | Submission_2026-03-23_07:37:10.906.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chuen Lam |
| SpeciesList | scientific name: Cavia; NCBI TaxID: NEWT:10140; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-08 15:04:24 | ID requested | |
| ⏵ 1 | 2026-03-23 07:37:11 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
Contact List
| Thomas LAM |
|---|
| contact affiliation | The HongKong polytechnic University |
| contact email | cclam@polyu.edu.hk |
| lab head | |
| Chuen Lam |
|---|
| contact affiliation | The Hong Kong Polytechnic University/School of optometry |
| contact email | cclam@polyu.edu.hk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD074201 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074201
- Label: PRIDE project
- Name: Comprehensive retinal characterization of myopic guinea pigs after PI3K/AKT inhibition via data-independent acquisition on an Orbitrap Exploris 480 mass spectrometer.
