PXD074176 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mesoporous Silica Nanoparticles-based Formulations for Enhanced Oral Delivery of Peptide Drugs: a Case Study on Insulin |
| Description | Peptide drugs have revolutionized modern medicine owing to their high potency, selectivity, and excellent tolerability. However, oral delivery remains limited, and most peptide drugs are administered parenterally due to their inherent instability to proteolytic digestion and poor ability to cross gastrointestinal barriers, which hinders efficient absorption into the bloodstream. This study presents a multifunctional oral delivery system based on mesoporous silica nanoparticles (MSN) customized for insulin administration. Insulin-loaded MSN (MSN(Ins)) were co-formulated with β-lactoglobulin to prevent premature gastric release, enabling delayed controlled intestinal delivery and protecting insulin from degradation. MSN functionalization with polyethylene glycol and phosphonate groups further enhanced MSN colloidal stability and insulin solubility. Phosphonated MSN, in particular, exhibited efficient interactions with intestinal cells, modulating the reorganization of tight junction proteins to promote the paracellular transport of MSN(Ins). Insulin delivered through these formulations retained its activity, as demonstrated by activation of insulin-responsive signaling pathways in vitro and reduction of blood glucose levels in hyperglycemic mice, hallmark responses of insulin treatment in type 2 diabetes. These findings highlight MSN as promising carriers for oral peptide delivery, supporting the development of effective, patient-friendly therapies with enhanced efficacy and compliance. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-24_16:13:50.212.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Christopher Gerner |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-06 22:38:32 | ID requested | |
| ⏵ 1 | 2026-05-24 16:13:51 | announced | |
Publication List
| 10.1002/smll.202513347; |
| Iriarte-Mesa C, Ju, è, re E, Bileck A, Kremsmayr T, Goodson ML, Ehrlich A, Hod, ž, i, ć A, Kunert M, Gerner C, K, ä, hlig H, Marko D, Muttenthaler M, Berry D, Del Favero G, Kleitz F, Mesoporous Silica Nanoparticles-Based Formulations for Enhanced Oral Delivery of Peptide Drugs: A Case Study on Insulin. Small, 22(24):e13347(2026) [pubmed] |
Keyword List
| submitter keyword: mesoporous silica nanoparticles (MSN) |
| peptide delivery |
| peptide drugs |
| proteomics,Insulin |
Contact List
| Christopher Gerner |
|---|
| contact affiliation | University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry |
| contact email | christopher.gerner@univie.ac.at |
| lab head | |
| Christopher Gerner |
|---|
| contact affiliation | University of Vienna |
| contact email | christopher.gerner@univie.ac.at |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD074176 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074176
- Label: PRIDE project
- Name: Mesoporous Silica Nanoparticles-based Formulations for Enhanced Oral Delivery of Peptide Drugs: a Case Study on Insulin
