PXD074155

PXD074155 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	HLA-DR MAPPs Assay in moDCs From 8 Donors Loaded With Infliximab
Description	MHC-associated peptide proteomics (MAPPs) enables direct identification of peptides naturally processed and presented by APCs, providing experimental evidence for antigen processing and HLA class II presentation. In this dataset published in PMID: 41085630, an HLA-DR–focused MAPPs workflow was used on monocyte-derived dendritic cells (moDCs) from 8 donors loaded with infliximab, enabling characterization of the infliximab-derived HLA-DR T cell epitopes for this HLA donor cohort. Samples were measured using a 30 spd Evosep One LC method and MS analysis on a timsTOF-SCP in DDA-PASEF mode.
HostingRepository	PRIDE
AnnounceDate	2026-02-13
AnnouncementXML	Submission_2026-02-13_04:12:39.417.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Van Doninck
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; deamidated residue
Instrument	timsTOF SCP

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-06 11:09:00	ID requested
⏵ 1	2026-02-13 04:12:43	announced

Publication List

Pepermans E, Sauna ZE, Pattyn S, MHC II MAPPs for High-Confident Immunogenicity Risk Assessment of Biotherapeutics. Methods Mol Biol, 2980():329-348(2026) [pubmed]
10.1007/978-1-0716-4832-2_16;

Pepermans E, Sauna ZE, Pattyn S, MHC II MAPPs for High-Confident Immunogenicity Risk Assessment of Biotherapeutics. Methods Mol Biol, 2980():329-348(2026) [pubmed]

10.1007/978-1-0716-4832-2_16;

Keyword List

submitter keyword: None

submitter keyword: None

Contact List

Elise Pepermans
contact affiliation	Immunespec Niel, Belgium
contact email	elise@immunespec.com
lab head
Thomas Van Doninck
contact affiliation	ImmuneSpec
contact email	thomas.vandoninck@immunespec.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD074155
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD074155

PRIDE project URI

Repository Record List

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