PXD074143 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Exploring the molecular mechanism of bone metastasis in prostate cancer |
| Description | This study focuses on bone metastasis of prostate cancer. By analyzing clinical samples and serum samples, it aims to reveal key molecular mechanisms and explore diagnostic and therapeutic targets. The specific goals include: First, identifying molecular markers related to bone metastasis, using high-throughput sequencing and proteomics analysis to screen for differentially expressed genes, proteins or ssDNA sequences; Second, analyzing the functions and mechanisms of key molecules, clarifying their roles in the interaction between tumor cells and the bone microenvironment through cell and animal experiments; Third, evaluating the potential of ssDNA as a new biomarker, studying its binding characteristics and the application value of liquid biopsy. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-01 |
| AnnouncementXML | Submission_2026-05-31_16:08:16.178.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Aaron Chen |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | biotinylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-06 03:28:02 | ID requested | |
| ⏵ 1 | 2026-05-31 16:08:16 | announced | |
Publication List
| Chen X, Ye MS, Peng ZL, Yan F, Xiao Y, Li YJ, Xiao Y, Single-stranded DNA in the bone microenvironment promotes prostate cancer bone metastasis via the ITGA6-FAK pathway. Commun Biol, 9(1):(2026) [pubmed] |
| 10.1038/s42003-026-09929-9; |
Keyword List
| submitter keyword: bone metastasis,Prostate cancer |
Contact List
| Ye Xiao |
|---|
| contact affiliation | Xiangya hospital, Central South University |
| contact email | 1577894960@qq.com |
| lab head | |
| Aaron Chen |
|---|
| contact affiliation | Central South University |
| contact email | aaron.chen1995@foxmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD074143 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074143
- Label: PRIDE project
- Name: Exploring the molecular mechanism of bone metastasis in prostate cancer
