⮝ Full datasets listing
PXD074101
PXD074101 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Developmental Reprogramming Underlies Chemotherapy Resistance in Favorable-Histology Wilms Tumor |
| Description | Children with favorable histology Wilms tumor (FHWT) who relapse or whose tumors show blastemal predominance post-chemotherapy often face poor outcomes. The purpose of this study is to identify mechanisms of chemotherapy resistance in FHWT. We induce a patient-derived xenograft model (KT-47) to develop blastemal predominance after chemotherapy and become resistant to vincristine, actinomycin-D, and doxorubicin (VAD). Multi-omics analyses reveal chromatin and transcriptional changes, including increased H3K4me3 and decreased H3K27me3 at stem cell and nephrogenesis gene loci. LIN28B is the most upregulated resistance-associated gene, linked to MYCN copy gain/upregulation and chromatin remodeling. ABCB1 expression correlates with inter-chromosomal enhancer interactions and functions as the mediator of chemotherapy resistance in vitro. These findings are validated in additional Wilms tumor models. Overall, resistance is associated with de-differentiation to a stem-like state and is driven ABCB1 upregulation, suggesting that therapeutic strategies targeting chromatin regulation and drug efflux may be relevant in therapy-resistant Wilms tumor. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-02-05 |
| AnnouncementXML | Submission_2026-02-05_12:00:05.292.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kiran Kodali |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Oxidation; Carbamidomethyl |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-05 11:46:57 | ID requested | |
| ⏵ 1 | 2026-02-05 12:00:05 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: TMT, DatasetType:Proteomics |
Contact List
| Andrew Murphy | |
|---|---|
| contact affiliation | St.Jude Children's Research Hospital |
| contact email | Andrew.Murphy@STJUDE.ORG |
| lab head | |
| Kiran Kodali | |
| contact affiliation | St.Jude Children's Research Hospital |
| contact email | kiran.kodali@stjude.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v12/MSV000100734/ |
