PXD074086

PXD074086 is an original dataset announced via ProteomeXchange.

Title	Erk3 deletion drives oxidative adaptations in skeletal muscle
Description	Skeletal muscle plays a central role in whole-body energy expenditure and metabolic homeostasis, and improving its mitochondrial function and oxidative fiber profile is considered an effective strategy to counteract diet-induced metabolic impairments, although the molecular regulators of these adaptations are not yet fully understood. Erk3 has been implicated in myotube differentiation and in skeletal muscle adaptations to aerobic exercise; however, its potential role in skeletal muscle during diet-induced metabolic dysfunction remains to be determined. Methods In this study, we used mice with striated muscle-specific Erk3 deletion alongside in vitro cultured myotubes, integrating metabolic phenotyping, indirect calorimetry, multi-omics profiling, and analyses of muscle morphology and fiber-type composition.
HostingRepository	PRIDE
AnnounceDate	2026-03-16
AnnouncementXML	Submission_2026-03-16_03:40:38.519.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Frank Stein
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-05 05:48:30	ID requested
⏵ 1	2026-03-16 03:40:39	announced

Loza-Valdes A, Acosta-Gallo C, Kassouf T, Belykh A, Stelmach M, Mali, ń, ska D, El Ghoz K, El-Merahbi R, Dziaczkowski F, Kolczy, ń, ska-Matysiak K, Sumara G, Erk3 deletion drives oxidative adaptations in skeletal muscle. Mol Metab, 106():102338(2026) [pubmed]

10.1016/j.molmet.2026.102338;

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: ekr3 mk5 muscle

Dioscuri Center for Metabolic Diseases
contact affiliation	Nencki Institute of Experimental Biology
contact email	k.kolczynska@nencki.edu.pl
lab head
Frank Stein
contact affiliation	EMBL
contact email	frank.stein@embl.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD074086

PRIDE project URI

• PRIDE
  1. PXD074086
     1. Label: PRIDE project
     2. Name: Erk3 deletion drives oxidative adaptations in skeletal muscle