PXD074024 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Serum proteomic profiling uncovers dysregulated keratinization and immune-related pathways in hidradenitis suppurativa. |
| Description | Hidradenitis suppurativa (HS) is an autoinflammatory keratinization disease affecting the pilosebaceous unit and hallmarked by a complex and multifactorial pathogenesis. In recent years, genetics and transcriptomics have been advancing in elucidating several crucial mechanisms underlying HS pathogenesis. Proteomic studies remain scarce, although serum proteomics holds great potential for capturing molecular signatures that reflect both cutaneous and systemic inflammation. This study presents a serum proteomic analysis of patients with moderate-to-severe HS, identifying 432 differentially expressed proteins out of 3,153 profiled. Enrichment analyses revealed dysregulated pathways related to keratinization, epidermal differentiation, and extracellular matrix remodeling, indicating impaired skin barrier function. Concurrent upregulation of immune-related pathways, including antibacterial responses and neutrophil degranulation, suggests systemic inflammation potentially linked to microbial dysbiosis. These findings support the dual role of epithelial dysfunction and autoinflammation in HS pathogenesis. Integration of proteomic data with genomic and transcriptomic findings underscores the value of multi-omics approaches in guiding targeted therapeutic development. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-06 |
| AnnouncementXML | Submission_2026-04-05_16:10:50.896.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Michelangelo Aloisio |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-03 18:46:02 | ID requested | |
| ⏵ 1 | 2026-04-05 16:10:51 | announced | |
Publication List
| 10.1111/exd.70244; |
| Moltrasio C, Roncar, à S, Ura B, Nardacchione EM, Sommella E, Moura R, Derlino F, Marzano AV, Crovella S, Tricarico PM, Serum Proteomic Profiling Uncovers Dysregulated Keratinisation and Immune-Related Pathways in Hidradenitis Suppurativa. Exp Dermatol, 35(4):e70244(2026) [pubmed] |
Keyword List
| submitter keyword: proteomics, keratinocyte,Acne inversa, immunity, skin inflammation |
Contact List
| Blendi Ura |
|---|
| contact affiliation | Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" |
| contact email | blendi.ura@burlo.trieste.it |
| lab head | |
| Michelangelo Aloisio |
|---|
| contact affiliation | National Institute of Gastroenterology S. De Bellis, IRCCS Research Hospital, |
| contact email | michelangelo.aloisio@irccsdebellis.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD074024 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074024
- Label: PRIDE project
- Name: Serum proteomic profiling uncovers dysregulated keratinization and immune-related pathways in hidradenitis suppurativa.
