PXD073844

PXD073844 is an original dataset announced via ProteomeXchange.

Title	Identification of ubiquitination sites on protein CSDE1 in SHSY5Y cells.
Description	This bottom-up proteomics dataset provides a global map of post-translational modifications (PTMs) on the RNA-binding protein CSDE1 in human neuroblastoma SHSY5Y cells. The data was acquired to survey the modification landscape of CSDE1, with a particular observation that lysine (K) residues displayed the most abundant modification signals among all amino acids. This unbiased survey informed subsequent functional studies investigating the role of specific modification sites. The relationship between CSDE1 and the E3 ligase MKRN2 was established in our prior research.
HostingRepository	PRIDE
AnnounceDate	2026-03-02
AnnouncementXML	Submission_2026-03-01_16:06:50.882.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zi Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	ubiquitination signature dipeptidyl lysine
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-30 08:37:12	ID requested
⏵ 1	2026-03-01 16:06:51	announced

10.3389/fncel.2026.1757304;

Wang Z, Han Y, Yang P, Jia C, Li C, Yuan S, Wei P, Hu R, Liquid-liquid phase separation couples MKRN2-mediated ubiquitination of CSDE1 with neurodevelopmental disorders. Front Cell Neurosci, 20():1757304(2026) [pubmed]

submitter keyword: MKRN2,CSDE1, ubiquitination site

Ronggui Hu
contact affiliation	Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou,China.
contact email	coryhu00@gmail.com
lab head
Zi Wang
contact affiliation	Shanghai Mental Health Center
contact email	wangzi0421@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD073844

PRIDE project URI

• PRIDE
  1. PXD073844
     1. Label: PRIDE project
     2. Name: Identification of ubiquitination sites on protein CSDE1 in SHSY5Y cells.