PXD073763

PXD073763 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Assessing the temporal proteomic changes in cancer cells surviving cisplatin or docetaxel treatment
Description	The goal of this project was to observe proteomic differences between cancer cells surviving chemotherapy (1-, 5-, and 10-Days post-treatment removal) and untreated parental cells. This provides us with a top-down view of pathways that could be enriched/down-regulated throughout those timepoints when compared to untreated parental cells and allow us to generate hypotheses to start new projects. The PC3 and MDA-MB-231 cell lines were used in this study.
HostingRepository	PRIDE
AnnounceDate	2026-06-08
AnnouncementXML	Submission_2026-06-07_16:09:13.725.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD073763
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sarah Amend
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-29 04:24:36	ID requested
⏵ 1	2026-06-07 16:09:14	announced

Publication List

Li M, Priem B, Loftus LV, Betenbaugh MJ, Pienta KJ, Amend SR, Polyploid cancer cells surviving cisplatin reallocate central carbon sources to fuel antioxidant metabolism for survival. Mol Metab, 108():102370(2026) [pubmed]
10.1016/j.molmet.2026.102370;
10.6019/PXD073763;

Li M, Priem B, Loftus LV, Betenbaugh MJ, Pienta KJ, Amend SR, Polyploid cancer cells surviving cisplatin reallocate central carbon sources to fuel antioxidant metabolism for survival. Mol Metab, 108():102370(2026) [pubmed]

10.1016/j.molmet.2026.102370;

10.6019/PXD073763;

Keyword List

submitter keyword: breast cancer, therapy resistance,Prostate cancer

submitter keyword: breast cancer, therapy resistance,Prostate cancer

Contact List

Sarah Amend
contact affiliation	School of Medicine Johns Hopkins University Baltimore, MD 21287, USA
contact email	Samend2@jhmi.edu
lab head
Sarah Amend
contact affiliation	Johns Hopkins University
contact email	samend2@jhmi.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD073763
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD073763

PRIDE project URI

Repository Record List

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