PXD073749

PXD073749 is an original dataset announced via ProteomeXchange.

Title	Lubricin-Inspired Janus Hydrogel Microspheres with Enhanced Lubrication and Anti-Inflammation through Cartilage Adhesion for Osteoarthritis Treatment
Description	Osteoarthritis (OA), a prevalent, disabling degenerative joint disorder, progresses due to cartilage lubrication failure and excessive inflammation. Inspired by the structure and function of natural lubricin on cartilage surface, this study develops Janus hydrogel microspheres with independent, asymmetric adhesive and lubricating compartments (Janus-Cur@Ms) via a biofriendly oil-free microfluidic platform. The spatially decoupled adhesive and lubricating functionalities enable stable cartilage adhesion, reduced off-target effect, and enhanced lubrication performance, thus overcoming the inherent conflict between adhesion and lubrication. This adhesion-enhanced lubrication synergizes with the anti-inflammatory effect of loaded curcumin, producing a combined therapeutic effect against OA. In vitro, Janus-Cur@Ms promote anabolism and suppress catabolism in primary chondrocytes, thereby restoring cellular function. In a rabbit OA model, Janus-Cur@Ms alleviate cartilage injury, delay joint space narrowing, inhibits pathological subchondral bone resorption, and reduces cartilage matrix loss, collectively attenuating OA progression. In summary, Janus-Cur@Ms simultaneously address multiple pathological hallmarks of OA through synergistic adhesion-enhanced lubrication and anti-inflammatory effects, demonstrating significant therapeutic efficacy.
HostingRepository	iProX
AnnounceDate	2026-01-29
AnnouncementXML	Submission_2026-01-28_23:09:27.696.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zichuan Ding
SpeciesList	scientific name: Oryctolagus cuniculus; NCBI TaxID: 9986;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-28 23:08:48	ID requested
⏵ 1	2026-01-28 23:09:28	announced

Dataset with its publication pending

submitter keyword: Janus hydrogel microspheres, oil-free microfluidic platform, adhesion, lubrication, osteoarthritis

Zongke Zhou
contact affiliation	West China Hospital
contact email	zhouzongke@scu.edu.cn
lab head
Zichuan Ding
contact affiliation	West China Hospital
contact email	dingzichuan@scu.edu.cn
dataset submitter

iProX dataset URI