⮝ Full datasets listing
PXD073700
PXD073700 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | UBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation |
| Description | Osteosarcoma (OS) responds poorly to immune-checkpoint blockade (ICB), and the molecular drivers of its immune-cold state remain unclear. Using multi-omics analyses, we identified an immune-cold OS subtype characterized by enrichment of protein SUMOylation and found the SUMO E1 subunit UBA2 as a key driver. UBA2 was anomalously upregulated in OS cohorts and linked to worse outcomes. Functionally, UBA2 promoted autophagy, thereby exerting noncanonical pro-tumor and immunosuppressive effects. Mechanistically, UBA2 catalyzed SUMO2-dependent SUMOylation of SESN2, enhancing autophagic flux. At the immune interface, UBA2 did not alter the expression of immune checkpoint molecules but reduced surface MHC-I through NBR1-mediated autophagy-lysosomal degradation, thereby limiting CD8⁺ T-cell infiltration. In vivo, pharmacologic UBA2 inhibition with ML-792 slowed tumor growth and sensitized tumors to ICB therapy. Together, these findings show that UBA2 links SUMOylation to autophagy-driven loss of antigen presentation and immune exclusion, highlighting the UBA2–autophagy–MHC-I axis as a therapeutic target and potential biomarker in OS. |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-28 |
| AnnouncementXML | Submission_2026-01-28_01:21:04.156.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lingfeng Yu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-28 01:19:45 | ID requested | |
| ⏵ 1 | 2026-01-28 01:21:04 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: UBA2, SUMOylation, SESN2, MHC-I, osteosarcoma |
Contact List
| Zhengdong Cai | |
|---|---|
| contact affiliation | Shanghai Bone Tumor Institutionl; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine |
| contact email | caizhengdong@sjtu.edu.cn |
| lab head | |
| Lingfeng Yu | |
| contact affiliation | Shanghai Bone Tumor Institutionl; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine |
| contact email | 1521056220@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
