PXD073699

PXD073699 is an original dataset announced via ProteomeXchange.

Title	Aspirin at plasma concentrations on embryo development using zebrafish model
Description	In obstetrics, aspirin is commonly prescribed for conditions such as preeclampsia and antiphospholipid syndrome. The usual dosage is 75 to 150 milligrams per day. It can cross the placenta and often used continuously during the entire pregnancy. Although high-dose animal studies have reported the developmental toxicities including neural tube defects and other structural abnormalities, the effects of plasma-level aspirin concentrations on embryogenesis remain poorly understood. In this study, we exposed zebrafish embryos to plasma - level concentrations of aspirin and observed dose-dependent decreases in heart rate, body length and locomotor activity ( measured by movement speed and distance), all changes were statistically significant. Additionally, the incidence of curled tails exhibited an upward trend, though it did not achieve statistical significance. In situ hybridization, transcriptomic, and epigenomic analyses revealed neurodevelopmental, muscular, cardiovascular, and renal abnormalities consistent with those reported in related studies. This paper outlines potential mechanisms linking differentially expressed genes and molecular modifications, providing a novel reference for evaluating the potential impacts of plasma - level aspirin concentrations on fetal development and guiding its clinical use during pregnancy.
HostingRepository	iProX
AnnounceDate	2026-01-28
AnnouncementXML	Submission_2026-01-28_01:18:34.734.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yutong Li
SpeciesList	scientific name: Danio rerio; NCBI TaxID: 7955;
ModificationList	No PTMs are included in the dataset
Instrument	QTRAP 6500+

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-28 01:18:10	ID requested
⏵ 1	2026-01-28 01:18:35	announced

Dataset with its publication pending

submitter keyword: Aspirin, plasma concentration, Toxicological assessment, Zebrafish, Embryo

Haiwen Liu
contact affiliation	The First Affiliated Hospital of Jinzhou Medical University
contact email	liuhw@jzmu.edu.cn
lab head
Yutong Li
contact affiliation	West China Second University Hospital, Sichuan University
contact email	unalee1002@163.com
dataset submitter

iProX dataset URI